Hydrazone linkages in pH responsive drug delivery systems
The hydrazone linkages, being pH-sensitive, find applications in drug delivery due to their faster hydrolysis rate at acidic pH relative to neutral physiological pH (Yoshida et al., 2013).The plausible mechanism involved in the hydrolytic breakdown of hydrazone linkage at acidic pH is shown in Fig. 1 (Yoshida et al., 2013).Various hydrazone linkages …
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